TY - JOUR
T1 - Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells
AU - Oishi, Tohru
AU - Konoki, Keiichi
AU - Tamate, Rie
AU - Torikai, Kohei
AU - Hasegawa, Futoshi
AU - Matsumori, Nobuaki
AU - Murata, Michio
N1 - Funding Information:
This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.
AB - Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.
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U2 - 10.1016/j.bmcl.2012.04.053
DO - 10.1016/j.bmcl.2012.04.053
M3 - Article
C2 - 22560474
AN - SCOPUS:84861185478
SN - 0960-894X
VL - 22
SP - 3619
EP - 3622
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 11
ER -