Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Yasuhiro Igarashi; Kazuki Yamamoto; Takao Fukuda; Akane Shojima; Jiro Nakayama; Lorena Carro; Martha E. Trujillo

doi:10.1021/acs.jnatprod.5b00540

Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Yasuhiro Igarashi, Kazuki Yamamoto, Takao Fukuda, Akane Shojima, Jiro Nakayama, Lorena Carro, Martha E. Trujillo

システム生物工学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

26 被引用数 (Scopus)

抄録

Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

本文言語	英語
ページ（範囲）	2827-2831
ページ数	5
ジャーナル	Journal of Natural Products
巻	78
号	11
DOI	https://doi.org/10.1021/acs.jnatprod.5b00540
出版ステータス	出版済み - 11月 25 2015

!!!All Science Journal Classification (ASJC) codes

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/acs.jnatprod.5b00540

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title = "Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.",

abstract = "Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.",

author = "Yasuhiro Igarashi and Kazuki Yamamoto and Takao Fukuda and Akane Shojima and Jiro Nakayama and Lorena Carro and Trujillo, {Martha E.}",

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AU - Igarashi, Yasuhiro

AU - Yamamoto, Kazuki

AU - Fukuda, Takao

AU - Shojima, Akane

AU - Nakayama, Jiro

AU - Carro, Lorena

AU - Trujillo, Martha E.

PY - 2015/11/25

Y1 - 2015/11/25

N2 - Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

AB - Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

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SN - 0163-3864

VL - 78

SP - 2827

EP - 2831

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

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!!!All Science Journal Classification (ASJC) codes

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