Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh; Jun Kuwahara; Kohji Itoh; Y. I. Fukuda; Mikiko Kohya; Mitsuru Shindo; Kozo Shishido

doi:10.1016/S0960-894X(02)00373-6

Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh
, Jun Kuwahara
, Kohji Itoh
, Y. I. Fukuda
, Mikiko Kohya
, Mitsuru Shindo
, Kozo Shishido

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

14 被引用数 (Scopus)

抄録

Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

本文言語	英語
ページ（範囲）	2069-2072
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	12
号	16
DOI	https://doi.org/10.1016/S0960-894X(02)00373-6
出版ステータス	出版済み - 8月 19 2002
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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title = "Apoptosis-Inducing activity of synthetic intermediates of Halichlorine",

abstract = "Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.",

author = "Midori Itoh and Jun Kuwahara and Kohji Itoh and Fukuda, \{Y. I.\} and Mikiko Kohya and Mitsuru Shindo and Kozo Shishido",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan. Financial support for K.S. was also provided by the Uehara Memorial Foundation. One of the authors (K.S.) is grateful for the generous financial support by the Uehara Memorial Foundation.",

year = "2002",

month = aug,

day = "19",

doi = "10.1016/S0960-894X(02)00373-6",

language = "English",

volume = "12",

pages = "2069--2072",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

AU - Itoh, Midori

AU - Kuwahara, Jun

AU - Itoh, Kohji

AU - Fukuda, Y. I.

AU - Kohya, Mikiko

AU - Shindo, Mitsuru

AU - Shishido, Kozo

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan. Financial support for K.S. was also provided by the Uehara Memorial Foundation. One of the authors (K.S.) is grateful for the generous financial support by the Uehara Memorial Foundation.

PY - 2002/8/19

Y1 - 2002/8/19

N2 - Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

AB - Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

UR - https://www.scopus.com/pages/publications/0037136021

UR - https://www.scopus.com/pages/publications/0037136021#tab=citedBy

U2 - 10.1016/S0960-894X(02)00373-6

DO - 10.1016/S0960-894X(02)00373-6

M3 - Article

C2 - 12127506

AN - SCOPUS:0037136021

SN - 0960-894X

VL - 12

SP - 2069

EP - 2072

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

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!!!All Science Journal Classification (ASJC) codes

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