Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support

TERUHIKO IMAMURA, NIKHIL NARANG, G. E.N.E. KIM, DAISUKE NITTA, TAKEO FUJINO, A. N.N. NGUYEN, JONATHAN GRINSTEIN, DANIEL RODGERS, TAKEYOSHI OTA, VALLUVAN JEEVANANDAM, GABRIEL SAYER, N. I.R. URIEL

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

Background: Aortic insufficiency (AI) is associated with morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs), whereas its impact on the HeartMate 3 LVAD cohorts remains uninvestigated. We aimed to investigate the clinical impact of AI on patients with HeartMate 3 LVADs. Methods and Results: Consecutive 61 patients (median age 54 years; 67% male) implanted with HeartMate 3 LVAD between 2015 and 2019 were enrolled and underwent echocardiography at 3 months after LVAD implantation. AI severity was quantified by the novel Doppler echocardiographic method obtained at the outflow cannula and the calculated regurgitation fraction of 30% or greater (moderate or greater) was defined as significant. At 3 months after implant, 12 patients (20%) had significant AI. They had a higher incidence of death or heart failure readmissions compared with those without significant AI during a 1-year observational period (70% vs 24%, P = .003) with an adjusted hazard ratio of 2.76 (95% confidence interval 1.03–7.88). Conclusions: In patients with HeartMate 3 LVAD support, significant AI remains both prevalent and a clinically significant downstream complication.

本文言語英語
ページ(範囲)863-869
ページ数7
ジャーナルJournal of Cardiac Failure
26
10
DOI
出版ステータス出版済み - 10月 2020
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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