Antioxidant Activity and Cytotoxicity of the Traditional Indonesian Medicine Tahongai (Kleinhovia hospita L.) Extract

Enos Tangke Arung, Irawan Wijaya Kusuma, Sri Purwatiningsih, Seong Soo Roh, Chae Ha Yang, Soohyeon Jeon, Yong Ung Kim, Edi Sukaton, Joko Susilo, Yuli Astuti, Britanto Dani Wicaksono, Ferry Sandra, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

20 被引用数 (Scopus)


We investigated the leaves of Kleinhovia hospita, a plant which has been traditionally used in Indonesia as phytotherapy to cure liver disease, to describe antioxidant materials from plant sources. K. hospita leaves were extracted with methanol and further partitioned into n-hexane, diethyl ether, and ethyl acetate. The antioxidant activity of each fraction and the residue was assessed using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and their cytotoxicity on HepG2 liver cancer cells was determined by a MTT assay. The K. hospita leaf methanol extract showed strong antioxidant activity (96%) compared with vitamin C (98%) by the DPPH method and the measured activity from the subsequent extracts of the methanol extract were 48.9% for n-hexane, 74.0% for diethyl ether, 84.3% for ethyl acetate, and 77.1% for the residue. The MTT assay showed the cytotoxicity of the methanol extract on HepG2 cells at 14%, 76%, and 80% at concentrations of 50μg/mL, 87.5μg/mL, and 125μg/mL, respectively. Leaf extracts of the medicinal plant K. hospita showed potent antioxidant activity and moderate cytotoxicity on HepG2 liver cancer cells.

ジャーナルJAMS Journal of Acupuncture and Meridian Studies
出版ステータス出版済み - 12月 2009

!!!All Science Journal Classification (ASJC) codes

  • 補完代替医療
  • 麻酔学および疼痛医療


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