Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds

Eri Hiraki, Shoko Furuta, Rika Kuwahara, Naomichi Takemoto, Toshiro Nagata, Taiki Akasaka, Bungo Shirouchi, Masao Sato, Koichiro Ohnuki, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿学術誌査読

18 被引用数 (Scopus)

抄録

Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids.

本文言語英語
ページ(範囲)482-491
ページ数10
ジャーナルJournal of Natural Medicines
71
3
DOI
出版ステータス出版済み - 7月 1 2017

!!!All Science Journal Classification (ASJC) codes

  • 分子医療

フィンガープリント

「Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル