Anti-androgen effects of extracts and compounds from Ganoderma lucidum

Jie Liu, Sadaaki Tamura, Kenji Kurashiki, Kuniyoshi Shimizu, Kiyoshi Noda, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

21 被引用数 (Scopus)

抄録

The 30% EtOH extracts of Ganoderma lucidum FR. KARST (Ganodermateceae) showed weak 5α-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.

本文言語英語
ページ(範囲)231-243
ページ数13
ジャーナルChemistry and Biodiversity
6
2
DOI
出版ステータス出版済み - 2009

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 生化学
  • 化学一般
  • 分子医療
  • 分子生物学

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