Analysis of superhelical structures of nucleic acid-lipid conjugates by image processing.

H. Yanagawa, Y. Ogawa, H. Furuta, K. Tsuno

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.

本文言語英語
ページ(範囲)189-192
ページ数4
ジャーナルNucleic acids symposium series
19
出版ステータス出版済み - 1988
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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