TY - GEN
T1 - Analysis for effect of cell shape on hippo signaling pathway using micro-fabricated cell culture platform
AU - Wada, Ken Ichi
AU - Itoga, Kazuyoshi
AU - Okano, Teruo
AU - Yonemura, Shigenobu
AU - Sasaki, Hiroshi
PY - 2012
Y1 - 2012
N2 - Cell density affects Hippo signals, which regulates cell proliferation, but its molecular mechanism is still unclear. In this study, we examined the effect of cell shape on Hippo pathway by using micro fabricated cell culture platform and found that F-actin formation was modulated by cell shapes and F-actin had an inhibitory effect on Hippo pathway. This findings suggest that cell shape is an important factor in the regulation of cell proliferation via Hippo signaling, and that cells can detect density through their resulting morphology by F-actin mediated mechanism to regulate proliferation.
AB - Cell density affects Hippo signals, which regulates cell proliferation, but its molecular mechanism is still unclear. In this study, we examined the effect of cell shape on Hippo pathway by using micro fabricated cell culture platform and found that F-actin formation was modulated by cell shapes and F-actin had an inhibitory effect on Hippo pathway. This findings suggest that cell shape is an important factor in the regulation of cell proliferation via Hippo signaling, and that cells can detect density through their resulting morphology by F-actin mediated mechanism to regulate proliferation.
UR - http://www.scopus.com/inward/record.url?scp=84901761345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901761345&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84901761345
SN - 9780979806452
T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
SP - 1051
EP - 1053
BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PB - Chemical and Biological Microsystems Society
T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Y2 - 28 October 2012 through 1 November 2012
ER -