TY - JOUR
T1 - Amelioration of delayed-type hypersensitivity responses by IL-27 administration
AU - Miyazaki, Yoshiyuki
AU - Shimanoe, Yohei
AU - Wang, Seng
AU - Yoshida, Hiroki
N1 - Funding Information:
The authors thank Dr. Hara for helpful discussion, Ms. Baba for animal husbandry, and Ms. Furukawa for secretarial support. This work was in part supported by grants from the Ministry of Education, Science, Technology, Sports and Culture of Japan (Y.M. and H.Y.), from Japan Research Foundation for Clinical Pharmacology (H.Y.), from the Sumitomo Foundation, Grant for Basic Science Research Projects (H.Y.), from the Naito Foundation (H.Y.), and from the Takeda Science Foundation (H.Y.). This work was also supported by the president’s expenditure (research project expenditure) of Saga University (H.Y.) and Saga University Board of Trustees Award 2007 (H.Y.).
PY - 2008/8/29
Y1 - 2008/8/29
N2 - Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor α chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder.
AB - Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor α chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder.
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U2 - 10.1016/j.bbrc.2008.06.038
DO - 10.1016/j.bbrc.2008.06.038
M3 - Article
C2 - 18572017
AN - SCOPUS:47249144061
SN - 0006-291X
VL - 373
SP - 397
EP - 402
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -