Rommy Von Bernhardi, Betsi Flores, Hiroshi Nakanishi

研究成果: 書籍/レポート タイプへの寄稿


Microglial cells undergo multiple morphological and immunophenotypic changes during normal aging. Abnormal morphology, which includes fewer and shorter ramifications, beading and spheroid swellings, has been observed particularly in the cerebral cortex, as well as in and around the white matter. In aged animals, microglia express some surface antigens which are not normally present in their young counterparts, in addition to presenting altered motility and phagocytosis. Aged microglia exhibit an aberrant production of pro- and anti-inflammatory mediators, accompanied by an exacerbated inflammatory response to pathological changes, a phenomenon known as microglial priming. Lysosomal dysfunction and mitochondrial DNA oxidative damage further accumulate in aged microglia, resulting in an increased production of reactive oxygen species. These changes could contribute to mediating the neuronal dysfunction observed during normal aging and facilitate the onset of age-associated cognitive decline, as well as neurodegenerative diseases. In this chapter, we describe microglial aging at the cellular and molecular levels, the implications for diseases, and potential strategies to slow down aging based on preserving lysosomal and mitochondrial function.

ホスト出版物のタイトルMicroglia in Health and Disease
出版社Springer New York
ISBN(印刷版)1493914286, 9781493914289
出版ステータス出版済み - 7月 1 2014

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)
  • 神経科学(全般)