Aggregation of a double hydrophilic block glycopolymer: The effect of block polymer ratio

Double hydrophilic block glycopolymers (DHBGs) composed of glycopolymers and polyethylene glycol (PEG) aggregate in aqueous solution. However, there are no guidelines to direct and design DHBG aggregation. Herein, we investigated the effect of the ratio of glycopolymer length to PEG length on the structure, and report that structure size could be influenced by the block polymer ratio. Nine kinds of DHBG with different glycopolymers and PEG lengths were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The aggregation capability of DHBG was investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In all cases, the DHBGs formed the spherical structures, even when the PEG and glycopolymer lengths were quite different. The size of the structure was controlled by the ratio of the PEG length to the glycopolymer length. The aggregation of the DHBGs was induced by hydrogen bonding between the sugar moieties. The aggregation of the DHBG was affected by temperature and concentration.