TY - JOUR
T1 - Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice
AU - Tsuda, Makoto
AU - Suzuki, Tsutomu
AU - Misawa, Miwa
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid from The Tokyo Biochemical Research Foundation and a Research Grant from the Ministry of Health and Welfare to T. Suzuki. We wish to thank Ms. Sachiko Komiya and Ms. Miho Soma for their expert technical assistance.
PY - 1997/12/19
Y1 - 1997/12/19
N2 - The developmental change in the antiseizure effect of ifenprodil against pentylenetetrazole (PTZ) was examined in mice. Ifenprodil (i.p.) significantly increased the latency to seizure induced by PTZ in 7- and 10- day-old mice, but not in 14- or 21-day-old mice. Intracerebroventricular administration of ifenprodil also failed to modify the latency to PTZ- induced seizure in 21-day-old mice. Dizocilpine produced an increase in the latency to PTZ-induced seizure in 7- and 21-day-old mice. In an NMDA receptor binding assay using [3H]dizocilpine, ifenprodil was clearly more potent in inhibiting [3H]dizocilpine binding in a forebrain membrane preparation from 7- rather than 21-day-old mice. These results suggest that the remarkable antiseizure effect of ifenprodil against PTZ in 7-day-old mice may be related to the high proportion of ifenprodil-sensitive NMDA receptors in the brain.
AB - The developmental change in the antiseizure effect of ifenprodil against pentylenetetrazole (PTZ) was examined in mice. Ifenprodil (i.p.) significantly increased the latency to seizure induced by PTZ in 7- and 10- day-old mice, but not in 14- or 21-day-old mice. Intracerebroventricular administration of ifenprodil also failed to modify the latency to PTZ- induced seizure in 21-day-old mice. Dizocilpine produced an increase in the latency to PTZ-induced seizure in 7- and 21-day-old mice. In an NMDA receptor binding assay using [3H]dizocilpine, ifenprodil was clearly more potent in inhibiting [3H]dizocilpine binding in a forebrain membrane preparation from 7- rather than 21-day-old mice. These results suggest that the remarkable antiseizure effect of ifenprodil against PTZ in 7-day-old mice may be related to the high proportion of ifenprodil-sensitive NMDA receptors in the brain.
UR - https://www.scopus.com/pages/publications/0031578936
UR - https://www.scopus.com/pages/publications/0031578936#tab=citedBy
U2 - 10.1016/S0165-3806(97)00140-5
DO - 10.1016/S0165-3806(97)00140-5
M3 - Article
C2 - 9466723
AN - SCOPUS:0031578936
SN - 0165-3806
VL - 104
SP - 201
EP - 204
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 1-2
ER -