Acute Swine Model for Assessing Biocompatibility of Biomedical Interface Materials

Tohru Takaseya, Hideyuki Fumoto, Junmin Zhu, Akira Shiose, Mariko Kobayashi, Masako Fujiki, Yoko Arakawa, Raymond Dessoffy, Larry D. Kramer, Kiyotaka Fukamachi

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)


We established an acute animal model for early, straightforward, and reproducible assessment of a biocompatible material interface. Bilateral femoral artery-to-vein shunts were created in 12 pigs: Two tubes per shunt, the left two coated and the right two uncoated. We evaluated two groups: Uncontrolled flow (UF; shunt flow unregulated) and controlled flow (CF; shunt flow ∼50 mL/min). For each case on each side, two shunts were evaluated: One for 1 h and the other for 3 h. Arterial blood gas and complete blood count were recorded at baseline, 1, and 3 h. Mean shunt flows were 532 ± 88 mL/min UF and 52 ± 8 mL/min CF. Differences in flow were much smaller in CF (0.5 mL/min; 1% of mean flow) than UF (24.8 mL/min; 5% of mean flow). In UF, significant changes occurred: In pH, from start of shunting through 1 h; in pO2 and pCO2, from start through 3 h. This swine model using bilateral femoral shunts with controlled blood flow provides a reliable, reproducible, easily implemented method by which to evaluate biocompatibility of device coatings at an early stage of investigation.

ジャーナルTissue Engineering - Part C: Methods
出版ステータス出版済み - 2月 2018

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体医工学


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