TY - JOUR
T1 - Acute ‘bilineal‐biphenotypic’ leukaemia
AU - Akashi, Koichi
AU - Shibuya, Tsunefumi
AU - Harada, Mine
AU - Morioka, Eiji
AU - Oshima, Koichi
AU - Kimura, Nobuhiro
AU - Takeshita, Morishige
AU - Kurokawa, Mamoru
AU - Kikuchi, Masahiro
AU - Niho, Yoshiyuki
PY - 1990/4
Y1 - 1990/4
N2 - We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.
AB - We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.
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U2 - 10.1111/j.1365-2141.1990.tb06326.x
DO - 10.1111/j.1365-2141.1990.tb06326.x
M3 - Article
C2 - 2189487
AN - SCOPUS:0025270752
SN - 0007-1048
VL - 74
SP - 402
EP - 407
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 4
ER -