A variant of metabotropic glutamate receptor subtype 5: An evolutionally conserved insertion with no termination codon

Reiko Minakami, Fujika Katsuki, Hiroyuki Sugiyama

研究成果: ジャーナルへの寄稿学術誌査読

99 被引用数 (Scopus)

抄録

We herein report the presence of a variant of the rat metabotropic glutamate receptor subtype 5 (mGluR5) cDNA. In this variant, named mGluR5b, an extra 96 bp sequence is inserted into the originally reported mGluR5 cDNA. The position of this insertion corresponds to that of the 85 bp insertion reported for the alternative form of mGluR1, another subtype of the receptors (designated as mGluR1β). No sequence-similarity was found between the additional sequences of mGluR1β and the mGluR5b. While the additional sequence of the mGluR1β cDNA contains a translation termination codon in the frame, that of the mGluR5b cDNA does not. This identical 96 bp insertion was also found in a human mGluR5 cDNA clone. Northern blot analyses with the mGluR5b specific probe showed that the expression of mRNA for this species is regulated in a region-specific manner in the rat brain.

本文言語英語
ページ(範囲)622-627
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
194
2
DOI
出版ステータス出版済み - 7月 30 1993

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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