Purpose: By using three-dimensional (3-D) CT imaging, the maxillofacial bones and muscles can be observed from any desired angles and analyzed the bone and muscles simultaneously. However, no studies have investigated the three dimensional analysis of muscles in jaw deformity. The purpose of this study was to examine the relationship between the morphology of the masticatory muscles and the craniofacial skeleton in the patients with facial asynmetry. Methods: Eight Japanese normal female adults and 10 female adult patients with laterognqthism were participated in this study. The 3-D CT images of their craniofacial skeleton and masseter, medial pterygoid and lateral pterygoid muscles were recon-structed. Then, 6 skeletal and 7 muscle variables were measured for each subject. Results: Significant positive correlations were found among the volume of the masti-catory muscles in the normal adults, but not found in patients with mandibular laterognathism. The muscular variables showed significant positive correlations with skeletal variables in normal subjects, but few significant correlations were found in the patients with laterognathism. Conclusions: This study suggestted that the balance between masticatory muscles and the balance between muscles and skeleton collapsed in the patients with mandibu-lar laterognathism.
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