A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Yasodha Sivasothy, Kong Yong Loo, Kok Hoong Leong, Marc Litaudon, Khalijah Awang

研究成果: ジャーナルへの寄稿学術誌査読

39 被引用数 (Scopus)

抄録

A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

本文言語英語
ページ(範囲)265-269
ページ数5
ジャーナルPhytochemistry
122
DOI
出版ステータス出版済み - 2月 1 2016
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 植物科学
  • 園芸学

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