A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto; Kenji Kawamura; Daisuke Asai; Takeshi Mori; Takurou Niidome; Yoko Shoji; Hideki Nakashima; Yoshiki Katayama

A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto
, Kenji Kawamura
, Daisuke Asai
, Takeshi Mori
, Takurou Niidome
, Yoko Shoji
, Hideki Nakashima
, Yoshiki Katayama

研究成果: 会議への寄与タイプ › 学会誌 › 査読

抄録

We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

本文言語	英語
ページ	4867
ページ数	1
出版ステータス	出版済み - 2006
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本継続期間: 9月 20 2006 → 9月 22 2006

その他

その他	55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域	日本
City	Toyama
Period	9/20/06 → 9/22/06

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

SDG 3 すべての人に健康と福祉を

!!!All Science Journal Classification (ASJC) codes

工学一般

他のファイルとリンク

引用スタイル

@conference{4043182d59214622a0f7506244aab0c4,

title = "A novel gene carrier for the therapy of viral infection disease",

abstract = "We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.",

author = "Masanori Kuramoto and Kenji Kawamura and Daisuke Asai and Takeshi Mori and Takurou Niidome and Yoko Shoji and Hideki Nakashima and Yoshiki Katayama",

year = "2006",

language = "English",

pages = "4867",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - A novel gene carrier for the therapy of viral infection disease

AU - Kuramoto, Masanori

AU - Kawamura, Kenji

AU - Asai, Daisuke

AU - Mori, Takeshi

AU - Niidome, Takurou

AU - Shoji, Yoko

AU - Nakashima, Hideki

AU - Katayama, Yoshiki

PY - 2006

Y1 - 2006

N2 - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

AB - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

UR - https://www.scopus.com/pages/publications/33846144803

UR - https://www.scopus.com/pages/publications/33846144803#tab=citedBy

M3 - Paper

AN - SCOPUS:33846144803

SP - 4867

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

A novel gene carrier for the therapy of viral infection disease

抄録

その他

UN SDG

!!!All Science Journal Classification (ASJC) codes

他のファイルとリンク

フィンガープリント

引用スタイル