TY - JOUR
T1 - A new insight into the lens
T2 - cytosolic PLAAT phospholipases degrade organelles to make the lens transparent
AU - Morishita, Hideaki
AU - Eguchi, Tomoya
AU - Mizushima, Noboru
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.
AB - All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.
UR - http://www.scopus.com/inward/record.url?scp=85110099637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110099637&partnerID=8YFLogxK
U2 - 10.1080/15548627.2021.1950372
DO - 10.1080/15548627.2021.1950372
M3 - Article
C2 - 34233574
AN - SCOPUS:85110099637
SN - 1554-8627
VL - 17
SP - 2645
EP - 2647
JO - Autophagy
JF - Autophagy
IS - 9
ER -