TY - JOUR
T1 - A new cycloartane triterpene and other phytoconstituents from the aerial parts of Euphorbia dendroides
AU - Hassan, Ahmed R.
AU - Ashour, Ahmed
AU - Amen, Yhiya
AU - Nagata, Maki
AU - El-Toumy, Sayed A.
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
The Egyptian Ministry of Higher Education and Scientific Research is acknowledged for the Post-doctoral fellowship support to Ahmed R. Hassan. We would like to express our gratitude to Prof. Tomofumi Miyamoto, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, for carrying out the optical rotation measurement. We would like also to thank Ms. Noriko Yazawa for measurement of Bruker DRX 600 NMR spectrometer and Mr. Toshio Nishi, Evaluation Center of Materials Properties and Function, IMCE, Kyushu University for measurement of LR- and HR-FAB-MS.
Funding Information:
The Egyptian Ministry of Higher Education and Scientific Research is acknowledged for the Post-doctoral fellowship support to Ahmed R. Hassan. We would like to express our gratitude to Prof. Tomofumi Miyamoto, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, for carrying out the optical rotation measurement. We would like also to thank Ms. Noriko Yazawa for measurement of Bruker DRX 600 NMR spectrometer and Mr. Toshio Nishi, Evaluation Center of Materials Properties and Function, IMCE, Kyushu University for measurement of LR- and HR-FAB-MS.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - New cycloartane-type triterpene 23 R/S-3β-hydroxycycloart-24-ene-23-methyl ether 1a,b (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of Euphorbia dendroides L. (Euphorbiaceae). The known compounds (2–11) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound 1 (a,b) was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested for in vitro cytotoxicity against different cell lines. The new compound 1 (a,b) exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC50 values of 20.67 ± 0.72, 16.24 ± 0.53, 22.59 ± 0.94, 25.99 ± 0.31 and 40.50 ± 3.14 μM, respectively.
AB - New cycloartane-type triterpene 23 R/S-3β-hydroxycycloart-24-ene-23-methyl ether 1a,b (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of Euphorbia dendroides L. (Euphorbiaceae). The known compounds (2–11) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound 1 (a,b) was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested for in vitro cytotoxicity against different cell lines. The new compound 1 (a,b) exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC50 values of 20.67 ± 0.72, 16.24 ± 0.53, 22.59 ± 0.94, 25.99 ± 0.31 and 40.50 ± 3.14 μM, respectively.
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U2 - 10.1080/14786419.2020.1800693
DO - 10.1080/14786419.2020.1800693
M3 - Article
C2 - 32722993
AN - SCOPUS:85088820075
SN - 1478-6419
VL - 36
SP - 828
EP - 836
JO - Natural Product Research
JF - Natural Product Research
IS - 3
ER -