A Model of Transcriptional Activation of DNA by Loosening of Chromatin Structure

Yuko T. Sato, Daisuke Asai, Keiko Terada, Jeong Hun Kang, Takeshi Mori, Takuro Niidome, Hideki Nakashima, Yoshiki Katayama

研究成果: ジャーナルへの寄稿学術誌査読

抄録

As a model of transcriptional activation of DNA by loosening of chromatin structure, we have developed a polymeric complex of plasmid DNA and a cationic polymer (SRC-Y) bearing peptide moieties that are phosphorylatable by p60c-Src. After phosphorylation, the diffusion constant of DAPIintercalated plasmid DNA in SRC-Y/DNA particles increased, concomitantly with initiation of transcription, meaning that the access of preinitiation complex, which recruits RNA polymerase II to promoter sequences, to chromatin-packaged DNA for transcriptional initiation is governed by DNA strand mobility.

本文言語英語
ページ(範囲)1109-1112
ページ数4
ジャーナルChemistry Letters
51
12
DOI
出版ステータス出版済み - 12月 2022

!!!All Science Journal Classification (ASJC) codes

  • 化学一般

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