TY - JOUR
T1 - A functional model of the cytochrome c oxidase active site
T2 - Unique conversion of a heme-μ-peroxo-CuII intermediate into heme-superoxo/CuI
AU - Liu, Jin Gang
AU - Naruta, Yoshinori
AU - Tani, Fumito
PY - 2005/3/11
Y1 - 2005/3/11
N2 - (Chemical Equation Presented) Axial ligation of the heme moiety by a proximal imidazole group is observed in a novel cytochromec oxidase (CcO) active-site model 1 in which the copper ion is bound to a N-(2-hydroxyphenyl) imidazole moiety. Spectroscopic observations of 1 suggest the unique transformation of an initial heme-μ-peroxo-CuII species into a heme-superoxide/CuI intermediate in the course of the CcO oxygenation reaction at low temperature.
AB - (Chemical Equation Presented) Axial ligation of the heme moiety by a proximal imidazole group is observed in a novel cytochromec oxidase (CcO) active-site model 1 in which the copper ion is bound to a N-(2-hydroxyphenyl) imidazole moiety. Spectroscopic observations of 1 suggest the unique transformation of an initial heme-μ-peroxo-CuII species into a heme-superoxide/CuI intermediate in the course of the CcO oxygenation reaction at low temperature.
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U2 - 10.1002/anie.200462582
DO - 10.1002/anie.200462582
M3 - Article
C2 - 15723432
AN - SCOPUS:17044434330
SN - 1433-7851
VL - 44
SP - 1836
EP - 1840
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 12
ER -