TY - GEN
T1 - A design strategy of a bioreactor for platelet production using fluid force
AU - Kumon, Hiroki
AU - Sakuma, Shinya
AU - Nakamura, Sou
AU - Eto, Koji
AU - Arai, Fumihito
N1 - Publisher Copyright:
© 2017 IEEE.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2/28
Y1 - 2018/2/28
N2 - In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.
AB - In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.
UR - http://www.scopus.com/inward/record.url?scp=85050530927&partnerID=8YFLogxK
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U2 - 10.1109/MHS.2017.8305248
DO - 10.1109/MHS.2017.8305248
M3 - Conference contribution
AN - SCOPUS:85050530927
T3 - MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
SP - 1
EP - 2
BT - MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
Y2 - 3 December 2017 through 6 December 2017
ER -