TY - JOUR
T1 - A conservation law for virus infection kinetics in vitro
AU - Kakizoe, Yusuke
AU - Morita, Satoru
AU - Nakaoka, Shinji
AU - Takeuchi, Yasuhiro
AU - Sato, Kei
AU - Miura, Tomoyuki
AU - Beauchemin, Catherine A.A.
AU - Iwami, Shingo
N1 - Funding Information:
This research was supported in part by the Kyushu University Fund (Y.K.), JST CREST program (K.S. and S.I.), the Aihara Innovative Mathematical Modeling Project, JSPS , through the “Funding Program for World-Leading Innovative R & D on Science and Technology (FIRST Program)”, initiated by Council for Science and Technology Policy (to K.S. and S.I.), Takeda Science Foundation (to K.S.), Sumitomo Foundation Research Grant (to K.S.), Senshin Medical Research Foundation (to K.S.), Imai Memorial Trust for AIDS Research (to K.S.), Ichiro Kanehara Foundation (to K.S.), Kanae Foundation for the Promotion of Medical Science (to K.S.), Suzuken Memorial Foundation (to K.S.), Kyushu University Short-term Young Scholar Exchange Program, which is based on Japanese Ministry of Education, Culture, Sports, Science and Technology ’s grant The Program for Promoting the Enhancement of Research Universities (C.A.A.B. and S.I.), JST PRESTO program (S.I.), Grants-in-Aid for Young Scientists B25800092 from the Japan Society for the Promotion of Science or JSPS (S.I.), with additional funding from the Inamori Foundation (S.I.).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/7/7
Y1 - 2015/7/7
N2 - Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.
AB - Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.
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U2 - 10.1016/j.jtbi.2015.03.034
DO - 10.1016/j.jtbi.2015.03.034
M3 - Article
C2 - 25882746
AN - SCOPUS:84928155228
SN - 0022-5193
VL - 376
SP - 39
EP - 47
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -