TY - GEN
T1 - A computational model of myocardial microcirculation including interstitial flow
AU - Shimayoshi, Takao
AU - Yamamoto, Yuta
AU - Matsuda, Tetsuya
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Contributions of interstitial fluid (ISF) flow within the myocardial microcirculation is not well understood despite its importance due to difficulties in measurements. For analysing a contribution of interstitial fluid flow within myocardial microcirculation, we developed a computational model of myocardial microcirculation by introducing convection by the ISF flow into an existing myocardial microcirculation model, and performed simulations with varied ISF flows in normal and hypoperfusion conditions. Simulation results show that the ISF flow has a contribution only with low capillary flow. This might suggest partial comensation of oxygen supply by the ISF flow under ischemic conditions.
AB - Contributions of interstitial fluid (ISF) flow within the myocardial microcirculation is not well understood despite its importance due to difficulties in measurements. For analysing a contribution of interstitial fluid flow within myocardial microcirculation, we developed a computational model of myocardial microcirculation by introducing convection by the ISF flow into an existing myocardial microcirculation model, and performed simulations with varied ISF flows in normal and hypoperfusion conditions. Simulation results show that the ISF flow has a contribution only with low capillary flow. This might suggest partial comensation of oxygen supply by the ISF flow under ischemic conditions.
UR - https://www.scopus.com/pages/publications/85032182729
UR - https://www.scopus.com/pages/publications/85032182729#tab=citedBy
U2 - 10.1109/EMBC.2017.8037653
DO - 10.1109/EMBC.2017.8037653
M3 - Conference contribution
C2 - 29060694
AN - SCOPUS:85032182729
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3668
EP - 3671
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -