A case of non-pigmented basal cell carcinoma on the dorsum of the nose

Hiromi Maemura, Nanae Kimura, Hiroko Takamatsu, Kayo Harada, Kazunori Urabe, Masutaka Furue

研究成果: ジャーナルへの寄稿学術誌査読


A 77-year-old woman visited us complaining of a nasal macule that had been gradually enlarging for 14 months. Previous topical corticosteroid application was ineffective. Physical examination revealed a hemorrhagic erythematous lesion with crust measuring 36 × 30 mm in diameter on the right side of her nose. On dermoscopy, telangiectasia and arborizing vessels were conspicuous without any pigmented spots or dots. Histopathologically, atypical basaloid cells were found to be proliferating in nests with peripheral palisading. However, melanin granules in the nests and peritumoral melanophages were not found, leading us to the diagnosis of non-pigmented basal cell carcinoma. Further immunohistological examination elucidated that Melan-A-positive melanocytes existed in the tumor nests; however, they were not stained by tyrosinase and Fontana-Masson staining. These results indicated that the inhibition of eumelanin biosynthesis in melanocytes would explain the hypopigmented nature of her basal cell carcinoma.

ジャーナルNishinihon Journal of Dermatology
出版ステータス出版済み - 2017

!!!All Science Journal Classification (ASJC) codes

  • 皮膚病学


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