A case of minocycline-induced pneumonitis

A 35-year-old man had been diagnosed as having urethritis and treated with minocycline. He developed dyspnea, fever, and cough on the 13th day after the administratim of minocycline. Chest X-ray and CT demonstrated multiple patchy infiltrates predominantly in the right upper and middle lung fields and nodular shadows in the bilateral middle and lower lung fields. Although minocycline was negative for lymphocyte stimulation test and patch test, the increased number of eosinophils and lymphocytes was noted in the peripheral blood and in the BALF. Since clinical symptoms, chest-X ray findings, and hypoxemia resolved after the discontinuance of minocycrine, this case was diagnosed as minocycline-induced eosinophilic pneuomonia.