4-META/MMA-TBB resin containing nano hydroxyapatite induces the healing of periodontal tissue repair in perforations at the pulp chamber floor

Hideki Sugii, Shinichiro Yoshida, Mhd Safwan Albougha, Sayuri Hamano, Daigaku Hasegawa, Tomohiro Itoyama, Junko Obata, Hiroshi Kaneko, Fumiko Minowa, Atsushi Tomokiyo, Hidefumi Maeda

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

We aimed to evaluate the materials based on 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate tri-n-butylborane (Super-bond [SB]) and nano hydroxyapatite (naHAp) for the repair of perforation at pulp chamber floor (PPF) in vitro and in vivo models. SB and naHAp were mixed in the mass ratio of 10% or 30% to produce naHAp/SB. Human periodontal ligament stem cells (HPDLSCs) were cultured on resin discs of SB or naHAp/SB to analyze the effects of naHAp/SB on cell adhesion, proliferation, and cementoblastic differentiation. A rat PPF model was treated with SB or naHAp/SB to examine the effects of naHAp/SB on the healing of defected cementum and periodontal ligament (PDL) at the site of PPF. HPDLSCs were spindle-shaped and adhered to all resin discs. Changing the resin from SB to naHAp/SB did not significantly alter cell proliferation. Both 10% and 30% naHAp/SB were more effective than SB in promoting cementoblastic differentiation of HPDLSCs. In the rat PPF model, 30% naHAp/SB was more effective than SB in promoting the formation Sharpey's fiber-like structures with expression of the PDL-related marker and cementum-like structures with expression of cementum-related markers. In conclusion, 30% naHAp/SB can be the new restorative material for PPF because it exhibited the abilities of adhering to dentin and healing of defected periodontal tissue.

本文言語英語
論文番号e4058
ジャーナルCell Biochemistry and Function
42
4
DOI
出版ステータス出版済み - 6月 2024

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 臨床生化学
  • 細胞生物学

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