3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki; Tohru Mizushima; Tomohiro Hashimoto; Minoru Maeda; Sekimizu Kazuhisa

doi:10.1016/S0960-894X(00)80378-9

3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki
, Tohru Mizushima
, Tomohiro Hashimoto
, Minoru Maeda
, Sekimizu Kazuhisa

医薬化学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

10 被引用数 (Scopus)

抄録

3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC₅₀=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.

本文言語	英語
ページ（範囲）	1771-1774
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	4
号	14
DOI	https://doi.org/10.1016/S0960-894X(00)80378-9
出版ステータス	出版済み - 7月 21 1994

!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

文献へのアクセス

10.1016/S0960-894X(00)80378-9

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引用スタイル

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abstract = "3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.",

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