After the Nobel Peace Prize 2006 was jointly awarded to Grameen Bank and M Yunus for work on microfinance 2006 and with the recent global economic crisis, micro finance institutions (MFIs) have been receiving global attention from the media, academia, financial institutions and government organizations. In particular, interest has turned to Grameen, ASA, and BRAC―the three Bangladesh based MFI giants with long operational experience―for information on creating MFIs with similar operational methodologies in the developed world. The wide network of these MFIs and their knowledge about the BOP population is necessary for BOP business co-ventures with the developed world. Grameen with its micro finance experience recently initiated implementing business to solve social problems under the new concept of social business. This paper introduces three large MFIs, their characteristics, growth and expansion; their role in ICT implementation for the reduction of the operational expenses; recent movement towards building regulatory alliances and the challenges ahead.