附属システム免疫学統合研究センター

2025

Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model

Ishii, Y., Shiota, A., Takao, T., Yamamoto, N., Ogawa, T., Jo, A., Shinozaki, S., Fukuyama, S., Koga, T., Ito, M., Tanaka, H., Tamura, A., Tsukita, S., Matsumoto, K., Okamoto, I. & Kan-o, K., 2025, (印刷中) In: Allergology International.

研究成果: ジャーナルへの寄稿 › レター › 査読

Comparative transcriptome and mutation analyses of the pancreatic islets of a rat model of obese type 2 diabetes identifies a frequently distributed nonsense mutation in the lipocalin 2 gene

Yokoi, N., Adachi, N., Hirokoji, T., Nakano, K., Yoshihara, M., Shigenaka, S., Urakawa, R., Taniguchi, Y., Yoshida, Y., Yokose, S., Suyama, M. & Okamura, T., 4月 1 2025, In: DNA Research. 32, 2, dsaf004.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Corrigendum to ‘MUC1-C Is a Common Driver of Acquired Osimertinib Resistance in NSCLC’ [Journal of Thoracic Oncology 19 Issue 3 (2024) 434-450, (S1556086423023481), (10.1016/j.jtho.2023.10.017)]

Haratake, N., Ozawa, H., Morimoto, Y., Yamashita, N., Daimon, T., Bhattacharya, A., Wang, K., Nakashoji, A., Isozaki, H., Shimokawa, M., Kikutake, C., Suyama, M., Hashinokuchi, A., Takada, K., Takenaka, T., Yoshizumi, T., Mitsudomi, T., Hata, A. N. & Kufe, D., 3月 2025, In: Journal of Thoracic Oncology. 20, 3, p. 399 1 p.

研究成果: ジャーナルへの寄稿 › コメント/討論 › 査読

Defining gene ends: RNA polymerase II CTD threonine 4 phosphorylation marks transcription termination regions genome-wide

Kopczyńska, M., Saha, U., Romanenko, A., Nojima, T., Gdula, M. R. & Kamieniarz-Gdula, K., 1月 27 2025, In: Nucleic acids research. 53, 2, gkae1240.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring

Takao, T., Matsui, A., Kikutake, C., Kan-o, K., Inoue, A., Suyama, M., Okamoto, I. & Ito, M., 12月 2025, In: Nature communications. 16, 1, 631.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

1 被引用数 (Scopus)

RANK drives structured intestinal epithelial expansion during pregnancy

Onji, M., Sigl, V., Lendl, T., Novatchkova, M., Ullate-Agote, A., Andersson-Rolf, A., Kozieradzki, I., Koglgruber, R., Pai, T. P., Lichtscheidl, D., Nayak, K., Zilbauer, M., Carranza García, N. A., Sievers, L. K., Falk-Paulsen, M., Cronin, S. J. F., Hagelkruys, A., Sawa, S., Osborne, L. C. & Rosenstiel, P. & 6 others, Pasparakis, M., Ruland, J., Takayanagi, H., Clevers, H., Koo, B. K. & Penninger, J. M., 1月 2 2025, In: Nature. 637, 8044, p. 156-166 11 p., e06930.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

Vγ6/Vδ1⁺ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice

Mahmoud, A. U. M., Caillon, A., Shokoples, B., Ferreira, N. S., Comeau, K., Hatano, S., Yoshikai, Y., Lewis, J. M., Tigelaar, R. E., Paradis, P. & Schiffrin, E. L., 1月 1 2025, In: Journal of hypertension. 43, 1, p. 109-119 11 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

3 被引用数 (Scopus)

2024

Bruton’s tyrosine kinase inhibition limits endotoxic shock by suppressing IL-6 production by marginal zone B cells in mice

Kawata, K., Hatano, S., Baba, A., Imabayashi, K. & Baba, Y., 2024, In: Frontiers in Immunology. 15, 1388947.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

Differences in the characteristics and functions of brain and spinal cord regulatory T cells

Watanabe, M., Matsui, A., Awata, N., Nagafuchi, A., Kawazoe, M., Harada, Y. & Ito, M., 12月 2024, In: Journal of neuroinflammation. 21, 1, 146.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

1 被引用数 (Scopus)

DNA-directed termination of mammalian RNA polymerase II

Davidson, L., Rouvière, J. O., Sousa-Luís, R., Nojima, T., Proudfoot, N. J., Jensen, T. H. & West, S., 11月 2024, In: Genes and Development. 38, 21-24, p. 998-1019 22 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells

Toh, H., Okae, H., Shirane, K., Sato, T., Hamada, H., Kikutake, C., Saito, D., Arima, T., Sasaki, H. & Suyama, M., 12月 2024, In: BMC genomics. 25, 1, 1050.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

Exome-wide benchmark of difficult-to-sequence regions using short-read next-generation DNA sequencing

Hijikata, A., Suyama, M., Kikugawa, S., Matoba, R., Naruto, T., Enomoto, Y., Kurosawa, K., Harada, N., Yanagi, K., Kaname, T., Miyako, K., Takazawa, M., Sasai, H., Hosokawa, J., Itoga, S., Yamaguchi, T., Kosho, T., Matsubara, K., Kuroki, Y. & Fukami, M. & 7 others, Adachi, K., Nanba, E., Tsuchida, N., Uchiyama, Y., Matsumoto, N., Nishimura, K. & Ohara, O., 1月 11 2024, In: Nucleic acids research. 52, 1, p. 114-124 11 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

4 被引用数 (Scopus)

Identification and analysis of short indels inducing exon extension/shrinkage events

Qu, Z., Sakaguchi, N., Kikutake, C. & Suyama, M., 10月 2024, In: FEBS Open Bio. 14, 10, p. 1682-1690 9 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration

Hirata, Y., Brems, H., Van der Auweraer, S., Ohyagi, M., Iizuka, M., Mise-Omata, S., Ito, M., Messiaen, L., Mizuno, S., Takahashi, S., Legius, E. & Yoshimura, A., 12月 2024, In: Journal of Biological Chemistry. 300, 12, 107969.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Modeling embryo-endometrial interface recapitulating human embryo implantation

Shibata, S., Endo, S., Nagai, L. A. E., Kobayashi, E. H., Oike, A., Kobayashi, N., Kitamura, A., Hori, T., Nashimoto, Y., Nakato, R., Hamada, H., Kaji, H., Kikutake, C., Suyama, M., Saito, M., Yaegashi, N., Okae, H. & Arima, T., 2月 2024, In: Science Advances. 10, 8, eadi4819.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

33 被引用数 (Scopus)

MUC1-C Is a Common Driver of Acquired Osimertinib Resistance in NSCLC

Haratake, N., Ozawa, H., Morimoto, Y., Yamashita, N., Daimon, T., Bhattacharya, A., Wang, K., Nakashoji, A., Isozaki, H., Shimokawa, M., Kikutake, C., Suyama, M., Hashinokuchi, A., Takada, K., Takenaka, T., Yoshizumi, T., Mitsudomi, T., Hata, A. N. & Kufe, D., 3月 2024, In: Journal of Thoracic Oncology. 19, 3, p. 434-450 17 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

16 被引用数 (Scopus)

NR4a1/2 deletion promotes accumulation of TCF1⁺ stem-like precursors of exhausted CD8⁺ T cells in the tumor microenvironment

Srirat, T., Hayakawa, T., Mise-Omata, S., Nakagawara, K., Ando, M., Shichino, S., Ito, M. & Yoshimura, A., 3月 26 2024, In: Cell Reports. 43, 3, 113898.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

9 被引用数 (Scopus)

NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors

Nakagawara, K., Ando, M., Srirat, T., Mise-Omata, S., Hayakawa, T., Ito, M., Fukunaga, K. & Yoshimura, A., 8月 16 2024, In: Journal for immunotherapy of cancer. 12, 8, e008665.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

Reconstruction of Sjögren's syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody

Iizuka-Koga, M., Ito, M., Yumoto, N., Mise-Omata, S., Hayakawa, T., Komai, K., Chikuma, S., Takahashi, S., Matsumoto, I., Sumida, T. & Yoshimura, A., 7月 2024, In: Clinical Immunology. 264, 110258.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Subtype-specific alternative splicing events in breast cancer identified by large-scale data analysis

Deguchi, Y., Kikutake, C. & Suyama, M., 12月 2024, In: Scientific reports. 14, 1, 14158.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Synovial-tissue resident macrophages play proinflammatory functions in the pathogenesis of RA while maintaining the phenotypes in the steady state

Kai, K., Yamada, H., Tsurui, R., Sakuraba, K., Fujimura, K., Kawahara, S., Akasaki, Y., Tsushima, H., Fujiwara, T., Hara, D., Fukushi, J. I., Sawa, S. & Nakashima, Y., 2024, In: Immunological Medicine. 47, 2, p. 58-67 10 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

1 被引用数 (Scopus)

The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity

Wakasa, T., Nonaka, K., Harada, A., Ohkawa, Y., Kikutake, C., Suyama, M., Kobunai, T., Tsunekuni, K., Matsuoka, K., Kataoka, Y., Ochiiwa, H., Miyadera, K., Sagara, T., Oki, E., Ohdo, S., Maehara, Y., Iimori, M. & Kitao, H., 12月 2024, In: Cell Death Discovery. 10, 1, 307.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

1 被引用数 (Scopus)

The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos

Shao, R., Suzuki, T., Suyama, M. & Tsukada, Y., 12月 2024, In: BMC genomics. 25, 1

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

3 被引用数 (Scopus)

The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models

Aki, D., Hayakawa, T., Srirat, T., Shichino, S., Ito, M., Saitoh, S. I., Mise-Omata, S. & Yoshimura, A., 12月 2 2024, In: Journal of Clinical Investigation. 134, 23, e175305.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

1 被引用数 (Scopus)

2023

CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development

Shimizu, T., Oike, A., Kobayashi, E. H., Sekiya, A., Kobayashi, N., Shibata, S., Hamada, H., Saito, M., Yaegashi, N., Suyama, M., Arima, T. & Okae, H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 51, e2311372120.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

14 被引用数 (Scopus)

Genome-wide identification of copy neutral loss of heterozygosity reveals its possible association with spatial positioning of chromosomes

Kim, H. & Suyama, M., 4月 1 2023, In: Human molecular genetics. 32, 7, p. 1175-1183 9 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

1 被引用数 (Scopus)

Homologous Recombination Repair Gene Alterations Are Associated with Tumor Mutational Burden and Survival of Immunotherapy

Ito, M., Kubo, M., Kawaji, H., Otsubo, Y., Kurata, K., Abutani, H., Suyama, M., Oda, Y., Yoshizumi, T., Nakamura, M. & Baba, E., 12月 2023, In: Cancers. 15, 23, 5608.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Immunity in the brain and surrounding tissues

Kanamori, M. & Ito, M., 3月 1 2023, In: Journal of biochemistry. 173, 3, p. 145-151 7 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

2 被引用数 (Scopus)

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease

Kaneko, R., Matsui, A., Watanabe, M., Harada, Y., Kanamori, M., Awata, N., Kawazoe, M., Takao, T., Kobayashi, Y., Kikutake, C., Suyama, M., Saito, T., Saido, T. C. & Ito, M., 12月 2023, In: Inflammation and Regeneration. 43, 1, 20.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

17 被引用数 (Scopus)

Microglia and macrophages in diseases

Kanamori, M., Harada, Y. & Ito, M., 2023, In: Folia Pharmacologica Japonica. 158, 4, p. 304-307 4 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Pan-cancer analysis of whole-genome doubling and its association with patient prognosis

Kikutake, C. & Suyama, M., 12月 2023, In: BMC Cancer. 23, 1, 619.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

Possible involvement of silent mutations in cancer pathogenesis and evolution

Kikutake, C. & Suyama, M., 12月 2023, In: Scientific reports. 13, 1, 7593.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

8 被引用数 (Scopus)

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages

Wilton, J., de Mendonça, F. L., Pereira-Castro, I., Tellier, M., Nojima, T., Costa, A. M., Freitas, J., Murphy, S., Oliveira, M. J., Proudfoot, N. J. & Moreira, A., 2023, In: Frontiers in Immunology. 14, 1182525.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

6 被引用数 (Scopus)

PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells

Iannone, C., Kainov, Y., Zhuravskaya, A., Hamid, F., Nojima, T. & Makeyev, E. V., 1月 19 2023, In: Molecular Cell. 83, 2, p. 203-218.e9

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

13 被引用数 (Scopus)

Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis

Oshima, K., Hinoki, A., Uchida, H., Tanaka, Y., Okuno, Y., Go, Y., Shirota, C., Tainaka, T., Sumida, W., Yokota, K., Makita, S., Takimoto, A., Kano, Y. & Sawa, S., 12月 2023, In: Pediatric surgery international. 39, 1, 179.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

2 被引用数 (Scopus)

SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

Mise-Omata, S., Ando, M., Srirat, T., Nakagawara, K., Hayakawa, T., Iizuka-Koga, M., Nishimasu, H., Nureki, O., Ito, M. & Yoshimura, A., 8月 29 2023, In: Cell Reports. 42, 8, 112940.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

7 被引用数 (Scopus)

T cells in the brain inflammation

Yoshimura, A., Ohyagi, M. & Ito, M., 1月 2023, Advances in Immunology. Alt, F. W. & Murphy, K. M. (eds.). Academic Press Inc., p. 29-58 30 p. (Advances in Immunology; vol. 157).

研究成果: 書籍/レポートタイプへの寄稿 › 章

Open Access

9 被引用数 (Scopus)

2022

Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics (Nature Reviews Molecular Cell Biology, (2022), 23, 6, (389-406), 10.1038/s41580-021-00447-6)

Nojima, T. & Proudfoot, N. J., 12月 2022, In: Nature Reviews Molecular Cell Biology. 23, 12, p. 853 1 p.

研究成果: ジャーナルへの寄稿 › コメント/討論 › 査読

Open Access

11 被引用数 (Scopus)

CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation

Tellier, M., Zaborowska, J., Neve, J., Nojima, T., Hester, S., Fournier, M., Furger, A. & Murphy, S., 10月 6 2022, In: EMBO Reports. 23, 10, e54520.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

18 被引用数 (Scopus)

Dermal Vγ6⁺ γδ T17 Cells Are Involved in Skin Pressure Ulcers in Mice

Mine, K., Tun, X., Hatano, S., Noguchi, N., Iwakura, Y., Sawa, S., Nagafuchi, S. & Yoshikai, Y., 8月 2022, In: Journal of Investigative Dermatology. 142, 8, p. 2294-2297.e5

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage

Yoshioka, Y., Anzai, K., Kowada, R., Hiratsuka, K., Hirayabu, T., Yasuda, M., Ohkawa, Y., Sato, T., Suyama, M., Yoshida, H. & Yamaguchi, M., 11月 1 2022, In: Experimental Cell Research. 420, 1, 113307.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Genome-wide identification of exon extension/shrinkage events induced by splice-site-creating mutations

Qu, Z., Sakaguchi, N., Kikutake, C. & Suyama, M., 2022, In: RNA biology. 19, 1, p. 1143-1152 10 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

1 被引用数 (Scopus)

Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing

Masuda, T., Haji, S., Nakashima, Y., Tsuda, M., Kimura, D., Takamatsu, A., Iwahashi, N., Umakoshi, H., Shiratsuchi, M., Kikutake, C., Suyama, M., Ohkawa, Y. & Ogawa, Y., 8月 19 2022, In: iScience. 25, 8, 104781.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

5 被引用数 (Scopus)

In Vitro Generation of Brain Regulatory T Cells by Co-culturing With Astrocytes

Yamamoto, S., Matsui, A., Ohyagi, M., Kikutake, C., Harada, Y., Iizuka-Koga, M., Suyama, M., Yoshimura, A. & Ito, M., 7月 15 2022, In: Frontiers in Immunology. 13, 960036.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

11 被引用数 (Scopus)

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

Mise, S., Matsumoto, A., Shimada, K., Hosaka, T., Takahashi, M., Ichihara, K., Shimizu, H., Shiraishi, C., Saito, D., Suyama, M., Yasuda, T., Ide, T., Izumi, Y., Bamba, T., Kimura-Someya, T., Shirouzu, M., Miyata, H., Ikawa, M. & Nakayama, K. I., 12月 2022, In: Nature communications. 13, 1, 1071.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

26 被引用数 (Scopus)

Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits

Kubota, N. & Suyama, M., 8月 2022, In: PLoS Computational Biology. 18, 8, e1010436.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

3 被引用数 (Scopus)

Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

Nojima, T. & Proudfoot, N. J., 6月 2022, In: Nature Reviews Molecular Cell Biology. 23, 6, p. 389-406 18 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

283 被引用数 (Scopus)

Pan-cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis

Kikutake, C. & Suyama, M., 10月 2022, In: Cancer Medicine. 11, 20, p. 3902-3916 15 p.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

4 被引用数 (Scopus)

Pervasive occurrence of splice-site-creating mutations and their possible involvement in genetic disorders

Sakaguchi, N. & Suyama, M., 12月 2022, In: npj Genomic Medicine. 7, 1, 22.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Open Access

8 被引用数 (Scopus)

Prostaglandin E₂ receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

Fleming, T., Kikuchi, Y., Nakajo, M., Tachizawa, M., Inazumi, T., Tsuchiya, S., Sugimoto, Y., Saito, D., Suyama, M., Ohkawa, Y., Baba, T., Morohashi, K. I. & Okubo, K., 12月 2022, In: Communications Biology. 5, 1, 1215.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

5 被引用数 (Scopus)

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