Zollinger-Ellison syndrome: Recent advances and controversies

Tetsuhide Ito, Hisato Igarashi, Robert T. Jensen

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)


Purpose of Review: To review the recent advances and current controversies in patients with Zollinger-Ellison syndrome (ZES). Recent Findings: Recent advances in the management of ZES include: improved understanding of the pathogenesis of gastrinoma and pancreatic neuroendocrine tumors, new prognostic classification systems, new diagnostic algorithms, more sensitive localization studies, new treatment strategies including improved control of gastric acid secretion and role for surgery, and new approaches to patients with advanced disease. Controversies include: the best approach to a patient with hypergastrinemia suspected of possibly having ZES, the appropriate gastrin assay to use, the role of surgery in patients with ZES, especially those with multiple endocrine neoplasia type 1, and the precise order of therapeutic modalities in the treatment of patients with advanced disease. Summary: This review updates clinicians regarding important advances and controversies required to optimally diagnose and manage patients with ZES.

Original languageEnglish
Pages (from-to)650-661
Number of pages12
JournalCurrent Opinion in Gastroenterology
Issue number6
Publication statusPublished - Nov 2013

All Science Journal Classification (ASJC) codes

  • Gastroenterology


Dive into the research topics of 'Zollinger-Ellison syndrome: Recent advances and controversies'. Together they form a unique fingerprint.

Cite this