Zinc finger-like motif conserved in a family of RNA binding proteins

Yuichi Matsushima; Kiyoshi Matsumura; Yasuo Kitagawa

doi:10.1271/bbb.61.905

Zinc finger-like motif conserved in a family of RNA binding proteins

Yuichi Matsushima, Kiyoshi Matsumura, Yasuo Kitagawa

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys₂-His₂ zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.

Original language	English
Pages (from-to)	905-906
Number of pages	2
Journal	Bioscience, Biotechnology and Biochemistry
Volume	61
Issue number	5
DOIs	https://doi.org/10.1271/bbb.61.905
Publication status	Published - Jan 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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AU - Kitagawa, Yasuo

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AB - NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys2-His2 zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.

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Zinc finger-like motif conserved in a family of RNA binding proteins

Abstract

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