Zinc finger-like motif conserved in a family of RNA binding proteins

Yuichi Matsushima, Kiyoshi Matsumura, Yasuo Kitagawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys2-His2 zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.

Original languageEnglish
Pages (from-to)905-906
Number of pages2
JournalBioscience, Biotechnology and Biochemistry
Issue number5
Publication statusPublished - Jan 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'Zinc finger-like motif conserved in a family of RNA binding proteins'. Together they form a unique fingerprint.

Cite this