TY - JOUR
T1 - ZGLP1 is a determinant for the oogenic fate in mice
AU - Nagaoka, So I.
AU - Nakaki, Fumio
AU - Miyauchi, Hidetaka
AU - Nosaka, Yoshiaki
AU - Ohta, Hiroshi
AU - Yabuta, Yukihiro
AU - Kurimoto, Kazuki
AU - Hayashi, Katsuhiko
AU - Nakamura, Tomonori
AU - Yamamoto, Takuya
AU - Saitou, Mitinori
PY - 2020/3/6
Y1 - 2020/3/6
N2 - Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.
AB - Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.
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U2 - 10.1126/science.aaw4115
DO - 10.1126/science.aaw4115
M3 - Article
C2 - 32054698
SN - 0036-8075
VL - 367
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 6482
ER -