Wnt Signaling in the Niche

Toshio Suda; Fumio Arai

doi:10.1016/j.cell.2008.02.017

Wnt Signaling in the Niche

Toshio Suda, Fumio Arai

Research output: Contribution to journal › Short survey › peer-review

43 Citations (Scopus)

Abstract

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

Original language	English
Pages (from-to)	729-730
Number of pages	2
Journal	Cell
Volume	132
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2008.02.017
Publication status	Published - Mar 7 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2008.02.017

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abstract = "There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.",

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AU - Arai, Fumio

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AB - There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

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JO - Cell

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Wnt Signaling in the Niche

Abstract

All Science Journal Classification (ASJC) codes

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