@article{06bb5060cce74ed78d5bac877906ea37,
title = "Widespread Inhibition, Antagonism, and Synergy in Mouse Olfactory Sensory Neurons In Vivo",
abstract = "Inagaki et al. demonstrate that odor produces not only excitatory but also inhibitory responses in mouse olfactory sensory neurons as a result of inverse agonism. They also find that responses to odor mixtures are extensively modulated by antagonism and synergy at the most peripheral level, depending on the odor concentrations.",
author = "Shigenori Inagaki and Ryo Iwata and Masakazu Iwamoto and Takeshi Imai",
note = "Funding Information: We thank KOMP and EUCOMM for ES clones (conditional Drd2 and Gabbr1); M. Yokoi (Pcdh21-Cre), I. Imayoshi (R26-CAG-LoxP-TeNT), K. Svoboda (Thy1-GCaMP6f), and P. Mombaerts (OMP-Cre knock-in) for mouse strains; V. Murthy for communicating unpublished results; and M. Leiwe for comments on the manuscript. Animal experiments, including generation of chimeric mice, were supported by the Laboratory for Animal Resources and Genetic Engineering at the RIKEN Center for Life Science Technologies. We appreciate the technical assistance by M. Nishihara, T. Ohmine, and The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. This work was supported by grants from the PRESTO program of the Japan Science and Technology Agency (JST), Japan (T.I.), the JSPS KAKENHI, Japan (grant number JP23680038 , JP15H05572 , JP15K14336 , JP16K14568 , JP16H06456 , and JP17H06261 to T.I. and JP15K18353 to R.I.), The Mochida Memorial Foundation for Medical and Pharmaceutical Research , intramural grant from RIKEN Center for Developmental Biology (T.I.), and Grant-in-Aid for JSPS Research Fellow, Japan ( JP15J08987 to R.I. and JP18J00899 to S.I.). Funding Information: We thank KOMP and EUCOMM for ES clones (conditional Drd2 and Gabbr1); M. Yokoi (Pcdh21-Cre), I. Imayoshi (R26-CAG-LoxP-TeNT), K. Svoboda (Thy1-GCaMP6f), and P. Mombaerts (OMP-Cre knock-in) for mouse strains; V. Murthy for communicating unpublished results; and M. Leiwe for comments on the manuscript. Animal experiments, including generation of chimeric mice, were supported by the Laboratory for Animal Resources and Genetic Engineering at the RIKEN Center for Life Science Technologies. We appreciate the technical assistance by M. Nishihara, T. Ohmine, and The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. This work was supported by grants from the PRESTO program of the Japan Science and Technology Agency (JST), Japan (T.I.), the JSPS KAKENHI, Japan (grant number JP23680038, JP15H05572, JP15K14336, JP16K14568, JP16H06456, and JP17H06261 to T.I. and JP15K18353 to R.I.), The Mochida Memorial Foundation for Medical and Pharmaceutical Research, intramural grant from RIKEN Center for Developmental Biology (T.I.), and Grant-in-Aid for JSPS Research Fellow, Japan (JP15J08987 to R.I. and JP18J00899 to S.I.). S.I. performed experiments and analyzed data. R.I. generated knockout and transgenic mice and performed initial rounds of imaging experiments. M.I. assisted with the OR assay. T.I. supervised the project. S.I. and T.I. wrote the manuscript with inputs from all authors. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jun,
day = "30",
doi = "10.1016/j.celrep.2020.107814",
language = "English",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}