Whole genome sequences of 2 octogenarians with sustained cognitive abilities

Dorothee Nickles, Lohith Madireddy, Nihar Patel, Noriko Isobe, Bruce L. Miller, Sergio E. Baranzini, Joel H. Kramer, Jorge R. Oksenberg

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Although numerous genetic variants affecting aging and mortality have been identified, for example, apolipoprotein E ε4, the genetic component influencing cognitive aging has not been fully defined yet. A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes. Here, we describe the whole genome sequences of 2 female octogenarians. We provide the repertoire of genomic variants that the 2 octogenarians have in common. We also describe the overlap with the previously reported genomes of 2 supercentenarians-individuals aged ≥110years. We assessed the genetic disease propensities of the octogenarians and non-aged control genomes and could not find support for the hypothesis that long-lived healthy individuals might exhibit greater genetic fitness than the general population. Furthermore, there is no evidence for an accumulation of previously described variants promoting longevity in the 2 octogenarians. These findings suggest that genetic fitness, as currently defined, is not the sole factor enabling an increased life span. We identified a number of healthy-cognitive-aging candidate genetic loci awaiting confirmation in larger studies.

Original languageEnglish
Pages (from-to)1435-1438
Number of pages4
JournalNeurobiology of Aging
Issue number3
Publication statusPublished - Mar 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Ageing
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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