Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia

Keita Terui, Yuko Tazuke, Kouji Nagata, Miharu Ito, Hiroomi Okuyama, Masahiro Hayakawa, Tomoaki Taguchi, Yasunori Sato, Noriaki Usui

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: Growth retardation is a severe morbidity in infants with congenital diaphragmatic hernia (CDH). This study aimed to determine when catch-up growth starts in infants with CDH and to determine the adequate amount of nutrition required during catch-up growth. Methods: This was a multicenter retrospective cohort study involving neonates with isolated CDH (born 2006–2010; n = 98). Weight gain velocity (WGV) was calculated using body weight Z-scores. The minimum required weight gain was defined as WGV ≥ 0. Patients were dichotomized into severe and non-severe cases according to diaphragmatic defects. Results: Average monthly WGV changed from < 0 to ≥ 0 at 2 months of age. Total caloric intake at 2 months of age was lower when the WGV between 1 and 3 months was < 0 in both severe cases [122 (95% confidence interval (CI) 116–128) vs. 97 (95% CI 84–110) kcal/kg/day, p = 0.02] and non-severe cases [115 (95% CI 110–120) vs. 99 (95% CI 87–111) kcal/kg/day, p < 0.001)]. Conclusion: Catch-up growth started at approximately 2 months of age. During this period, total caloric intake of > 122 kcal/kg/day was needed to avoid decreases in the body weight Z-score in severe cases.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalPediatric surgery international
Issue number2
Publication statusPublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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