WECHE: A novel hematopoietic regulatory factor

Osamu Ohneda; Kinuko Ohneda; Hisayuki Nomiyama; Zhong Zheng; Steven A. Gold; Fumio Arai; Takeshi Miyamoto; Bruce E. Taillon; Richard A. McIndoe; Richard A. Shimkets; David A. Lewin; Toshio Suda; Laurence A. Lasky

doi:10.1016/s1074-7613(00)80167-3

WECHE: A novel hematopoietic regulatory factor

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

Original language	English
Pages (from-to)	141-150
Number of pages	10
Journal	Immunity
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/s1074-7613(00)80167-3
Publication status	Published - Feb 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s1074-7613(00)80167-3

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title = "WECHE: A novel hematopoietic regulatory factor",

abstract = "Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.",

author = "Osamu Ohneda and Kinuko Ohneda and Hisayuki Nomiyama and Zhong Zheng and Gold, {Steven A.} and Fumio Arai and Takeshi Miyamoto and Taillon, {Bruce E.} and McIndoe, {Richard A.} and Shimkets, {Richard A.} and Lewin, {David A.} and Toshio Suda and Lasky, {Laurence A.}",

year = "2000",

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doi = "10.1016/s1074-7613(00)80167-3",

language = "English",

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T2 - A novel hematopoietic regulatory factor

AU - Ohneda, Osamu

AU - Ohneda, Kinuko

AU - Nomiyama, Hisayuki

AU - Zheng, Zhong

AU - Gold, Steven A.

AU - Arai, Fumio

AU - Miyamoto, Takeshi

AU - Taillon, Bruce E.

AU - McIndoe, Richard A.

AU - Shimkets, Richard A.

AU - Lewin, David A.

AU - Suda, Toshio

AU - Lasky, Laurence A.

PY - 2000/2

Y1 - 2000/2

N2 - Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

AB - Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

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JO - Immunity

JF - Immunity

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ER -

WECHE: A novel hematopoietic regulatory factor

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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