TY - JOUR
T1 - Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes
AU - Morishita, Kosuke
AU - Okamoto, Yuna
AU - Murayama, Shuhei
AU - Usui, Kazuteru
AU - Ohashi, Eriko
AU - Hirai, Go
AU - Aoki, Ichio
AU - Karasawa, Satoru
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/8/8
Y1 - 2017/8/8
N2 - Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.
AB - Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.
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U2 - 10.1021/acs.langmuir.7b01126
DO - 10.1021/acs.langmuir.7b01126
M3 - Article
C2 - 28678510
AN - SCOPUS:85027020230
SN - 0743-7463
VL - 33
SP - 7810
EP - 7817
JO - Langmuir
JF - Langmuir
IS - 31
ER -