Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Ying Lin; Yan Meng; Yan Xia Wang; Juan Luo; Susumu Katsuma; Cong Wen Yang; Yutaka Banno; Takahiro Kusakabe; Toru Shimada; Qing You Xia

doi:10.1074/jbc.M113.462556

Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Ying Lin, Yan Meng, Yan Xia Wang, Juan Luo, Susumu Katsuma, Cong Wen Yang, Yutaka Banno, Takahiro Kusakabe, Toru Shimada, Qing You Xia

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

Original language	English
Pages (from-to)	13345-13355
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	19
DOIs	https://doi.org/10.1074/jbc.M113.462556
Publication status	Published - May 10 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "Vitellogenin receptor mutation leads to the oogenesis mutant phenotype {"}scanty vitellin{"} of the silkworm, bombyx mori",

abstract = "Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.",

author = "Ying Lin and Yan Meng and Wang, {Yan Xia} and Juan Luo and Susumu Katsuma and Yang, {Cong Wen} and Yutaka Banno and Takahiro Kusakabe and Toru Shimada and Xia, {Qing You}",

year = "2013",

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doi = "10.1074/jbc.M113.462556",

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T1 - Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

AU - Lin, Ying

AU - Meng, Yan

AU - Wang, Yan Xia

AU - Luo, Juan

AU - Katsuma, Susumu

AU - Yang, Cong Wen

AU - Banno, Yutaka

AU - Kusakabe, Takahiro

AU - Shimada, Toru

AU - Xia, Qing You

PY - 2013/5/10

Y1 - 2013/5/10

N2 - Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

AB - Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

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Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Abstract

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