Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice

Kenichi Mishima, Takamitsu Tanaka, Fengling Pu, Nobuaki Egashira, Katsunori Iwasaki, Ryoji Hidaka, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


α-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. α-tocopherol (2 mM), α-tocotrienol (0.2 and 2 mM) and γ-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while γ-tocotrienol, δ-tocopherol and δ-tocotrienol showed no effect on the cerebral infarcts. These results suggest that α-tocotrienol and γ-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Jan 30 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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