Vitamin B 12 derivatives as activators of soluble guanylyl cyclase

Keith Ó Proinsias; Daniel T. Gryko; Yoshio Hisaeda; Emil Martin; Jonathan L. Sessler; Dorota Gryko

doi:10.1021/jm3006959

Vitamin B ₁₂ derivatives as activators of soluble guanylyl cyclase

Keith Ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Various newly prepared and previously known vitamin B ₁₂ derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

Original language	English
Pages (from-to)	8943-8947
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	55
Issue number	20
DOIs	https://doi.org/10.1021/jm3006959
Publication status	Published - Oct 25 2012

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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10.1021/jm3006959

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abstract = "Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.",

author = "{{\'O} Proinsias}, Keith and Gryko, {Daniel T.} and Yoshio Hisaeda and Emil Martin and Sessler, {Jonathan L.} and Dorota Gryko",

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AU - Ó Proinsias, Keith

AU - Gryko, Daniel T.

AU - Hisaeda, Yoshio

AU - Martin, Emil

AU - Sessler, Jonathan L.

AU - Gryko, Dorota

PY - 2012/10/25

Y1 - 2012/10/25

N2 - Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

AB - Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

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Vitamin B ₁₂ derivatives as activators of soluble guanylyl cyclase

Abstract

All Science Journal Classification (ASJC) codes

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