Vitamin B 12 derivatives as activators of soluble guanylyl cyclase

Keith Ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

    Original languageEnglish
    Pages (from-to)8943-8947
    Number of pages5
    JournalJournal of Medicinal Chemistry
    Issue number20
    Publication statusPublished - Oct 25 2012

    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Drug Discovery


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