Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells

Taiji Sakamoto; Hitomi Sakamoto; Todd L. Murphy; Christine Spee; Danilo Soriano; Tatsuro Ishibashi; David R. Hinton; Stephen J. Ryan

doi:10.1001/archopht.1995.01100040134039

Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells

Taiji Sakamoto, Hitomi Sakamoto, Todd L. Murphy, Christine Spee, Danilo Soriano, Tatsuro Ishibashi, David R. Hinton, Stephen J. Ryan

Kyushu University Hospital

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Overlying RPE cells stimulate the formation of tubelike structures by choroidal endothelial cells more effectively than do fibroblasts or pericytes but inhibit BCE tube formation in older cultures. The effect involves endothelial proliferation and differentiation. The stimulatory effect of overlying RPE cells can be inhibited by neutralizing antibodies to vascular endothelial growth factor and basic fibroblast growth factor, which suggests that these growth factors play an important role in this phenomenon.

Original language	English
Pages (from-to)	512-520
Number of pages	9
Journal	Archives of Ophthalmology
Volume	113
Issue number	4
DOIs	https://doi.org/10.1001/archopht.1995.01100040134039
Publication status	Published - Apr 1995

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1001/archopht.1995.01100040134039

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abstract = "Overlying RPE cells stimulate the formation of tubelike structures by choroidal endothelial cells more effectively than do fibroblasts or pericytes but inhibit BCE tube formation in older cultures. The effect involves endothelial proliferation and differentiation. The stimulatory effect of overlying RPE cells can be inhibited by neutralizing antibodies to vascular endothelial growth factor and basic fibroblast growth factor, which suggests that these growth factors play an important role in this phenomenon.",

author = "Taiji Sakamoto and Hitomi Sakamoto and Murphy, {Todd L.} and Christine Spee and Danilo Soriano and Tatsuro Ishibashi and Hinton, {David R.} and Ryan, {Stephen J.}",

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AU - Sakamoto, Taiji

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AU - Murphy, Todd L.

AU - Spee, Christine

AU - Soriano, Danilo

AU - Ishibashi, Tatsuro

AU - Hinton, David R.

AU - Ryan, Stephen J.

PY - 1995/4

Y1 - 1995/4

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AB - Overlying RPE cells stimulate the formation of tubelike structures by choroidal endothelial cells more effectively than do fibroblasts or pericytes but inhibit BCE tube formation in older cultures. The effect involves endothelial proliferation and differentiation. The stimulatory effect of overlying RPE cells can be inhibited by neutralizing antibodies to vascular endothelial growth factor and basic fibroblast growth factor, which suggests that these growth factors play an important role in this phenomenon.

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Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells

Abstract

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