Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Mitsuru Tanaka; Toshiro Matsui; Yusuke Ushida; Kiyoshi Matsumoto

doi:10.1271/bbb.60119

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Mitsuru Tanaka
, Toshiro Matsui
, Yusuke Ushida
, Kiyoshi Matsumoto

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

Original language	English
Pages (from-to)	2292-2295
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	9
DOIs	https://doi.org/10.1271/bbb.60119
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1271/bbb.60119

Cite this

@article{2407d27a33eb46338aaa5129aac2c561,

title = "Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats",

abstract = "In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.",

keywords = "ACE, Hypertension, Small peptides, Spontaneously hypertensive rat (SHR) aorta, Vascular relaxation",

author = "Mitsuru Tanaka and Toshiro Matsui and Yusuke Ushida and Kiyoshi Matsumoto",

note = "Funding Information: This research was supported by a Grand-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 15380094).",

year = "2006",

doi = "10.1271/bbb.60119",

language = "English",

volume = "70",

pages = "2292--2295",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

AU - Tanaka, Mitsuru

AU - Matsui, Toshiro

AU - Ushida, Yusuke

AU - Matsumoto, Kiyoshi

N1 - Funding Information: This research was supported by a Grand-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 15380094).

PY - 2006

Y1 - 2006

N2 - In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

AB - In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

KW - ACE

KW - Hypertension

KW - Small peptides

KW - Spontaneously hypertensive rat (SHR) aorta

KW - Vascular relaxation

UR - https://www.scopus.com/pages/publications/33749036553

UR - https://www.scopus.com/pages/publications/33749036553#tab=citedBy

U2 - 10.1271/bbb.60119

DO - 10.1271/bbb.60119

M3 - Article

C2 - 16960366

AN - SCOPUS:33749036553

SN - 0916-8451

VL - 70

SP - 2292

EP - 2295

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 9

ER -

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this