Vasodilating dipeptide Trp-His can prevent atherosclerosis in apo E-deficient mice

Toshiro Matsui, Masao Sato, Mitsuru Tanaka, Yasuna Yamada, Shimpei Watanabe, Yumiko Fujimoto, Katsumi Imaizumi, Kiyoshi Matsumoto

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Most of the investigations for an alternative medicinal treatment on atherosclerosis have been focused on natural or dietary compounds including phytochemicals. So far, few studies regarding anti-atherosclerotic small peptides except for tetrapeptide of Lys-Arg-Glu-Ser have been reported. The present study was, thus, to investigate whether dipeptide Trp-His, which is one of vasodilating small peptides, could reduce atherosclerotic lesions in apo E-deficient mice fed a high-fat diet. The animal study involved a 9-week-successive administration of Trp-His at a dose of 0, 10 or 100mg/kg per d. After 9-week administration, en face analyses provided the first direct evidence that the atherosclerotic lesion area was significantly reduced by 27 and 38% for Trp-His dosed at 10 and 100mg/kg per d, respectively, compared with the control group. Administration of Trp-His did not affect growth parameters such as body weight and feeding efficiency (P>01). Total serum cholesterol and HDL-cholesterol as well as lipid profiles in the liver did not differ between the tested groups. Taken together, the anti-atherosclerotic effect of dipeptide Trp-His should be addressed into physiological functions of bioactive peptides, in which the dipeptide may elicit the power by alternative mechanism(s), not by the regulation of lipid metabolism.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalBritish Journal of Nutrition
Issue number3
Publication statusPublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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