TY - GEN
T1 - Vascular remodeling processes in an integrated microfluidic device
AU - Futai, Nobuyuki
AU - Sano, Takanori
AU - Sumita, Masahiro
AU - Takano, Atsushi
AU - Yokokawa, Ryuji
AU - Miura, Takashi
N1 - Funding Information:
This work was supported by CREST “Spontaneous pattern formation ex vivo”, JST, Japan. We thank Mr. Shugo Maeda for device fabrication and cell culture on-chip.
Publisher Copyright:
© 17CBMS-0001.
PY - 2020
Y1 - 2020
N2 - We have succeeded in maintaining self-organized microvascular networks on-chip for over a month in a portable (71×26×28 mm) microfluidic co-culture system of endothelial cells and fibroblasts. We observed the long-term changes of microvascular networks in a microchannel. Perfusion through lumens may accelerate the remodeling processes. HUVECs formed stable lumens by around 100th day of cultivation, and the lumens could be maintained for at least 132 days.
AB - We have succeeded in maintaining self-organized microvascular networks on-chip for over a month in a portable (71×26×28 mm) microfluidic co-culture system of endothelial cells and fibroblasts. We observed the long-term changes of microvascular networks in a microchannel. Perfusion through lumens may accelerate the remodeling processes. HUVECs formed stable lumens by around 100th day of cultivation, and the lumens could be maintained for at least 132 days.
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M3 - Conference contribution
AN - SCOPUS:85079595965
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 1080
EP - 1081
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -