Vascular endothelial growth factor in chronic subdural haematomas

Tadahisa Shono, Takanori Inamura, Takato Morioka, Ken ichi Matsumoto, Satoshi O. Suzuki, Kiyonobu Ikezaki, Toru Iwaki, Masashi Fukui

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Objective. To elucidate molecular aspects of the mechanisms of expansion of chronic subdural haematomas (CSH), we examined the expression of two representative angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in CSH. Methods. We quantified VEGF and bFGF in haematoma fluid and serum of 20 patients with CSH using an enzyme-linked immunosorbent assay. Mean concentrations of VEGF in the haematoma fluid (10277 pg/ml) and in serum, (355 pg/ml) were much greater than those of bFGF (haematoma, 3.04 pg/ml; serum, 4.74 pg/ml). Surgical specimens, including dura and the outer membrane of the CSH were analysed by in situ hybridisation to detect VEGF mRNA. Macrophages and vascular endothelial cells in the outer membrane over expressed VEGF mRNA. Conclusions. Enhanced production of VEGF by macrophages and vascular endothelial cells in the outer membrane is thought to be pathogenetically important in CSH.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalJournal of Clinical Neuroscience
Issue number5
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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