Vanadyl Species Catalyzed 1,2-Oxidative Trifluoromethylation of Unactivated Olefins

Chien Tien Chen, Ya Pei Chen, Bang You Tsai, Yi Ya Liao, Yu Cheng Su, Tsung Cheng Chen, Chia Hao Lu, Ryoma Fujii, Kyohei Kawashima, Seiji Mori

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A catalytic protocol for "CF3"-radical type addition to terminal and β-substituted olefins with Togni's reagent to deliver various α-trifluoromethylated ketones of biomedicinal interests was examined by a series of oxovanadium species under oxygen atmosphere at ambient temperature. Among six different V(O)X2 bearing (bi)pyridine, imidazole, and (bis)oxazoline ligands and five different oxidovanadium complexes derived from N-salicylidene tert-leucinate, and salen ligands examined, the complexes with 3,5-dibromo substituents and VO(OTf)2 with bisoxazoline type ligands led to the best results.

Original languageEnglish
Pages (from-to)3676-3683
Number of pages8
JournalACS Catalysis
Volume10
Issue number6
DOIs
Publication statusPublished - Mar 20 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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